What are possible side effects of Succinylcholine (Anectine)?

Succinylcholine, a neuromuscular blocker commonly used in rapid sequence intubation, can lead to specific side effects due to its mechanism of action and pharmacological properties. The correct answer highlights fasciculations and hyperkalemia as significant potential side effects.

Fasciculations are brief, involuntary muscle contractions that occur right after administration of succinylcholine. This happens because succinylcholine acts as an agonist at the neuromuscular junction, causing initial depolarization of the muscle membrane. Such fasciculations may be seen as muscle twitches before the muscle relaxes completely.

Hyperkalemia, or elevated potassium levels in the blood, can occur as a result of the depolarizing effect of succinylcholine. Since fasciculations can lead to the release of potassium from muscle cells into the bloodstream, patients with underlying conditions such as burns, crush injuries, or neuromuscular diseases, where muscle cells may be damaged, are particularly at risk for significant increases in serum potassium levels after succinylcholine administration.

Overall, the presence of fasciculations and the risk of hyperkalemia are critical considerations when using succinylcholine in patients, especially in critical care settings.