What is Addison's disease primarily a deficiency of?

Addison's disease is primarily characterized by a deficiency of adrenal hormones, specifically glucocorticoids (like cortisol) and often mineralocorticoids (like aldosterone). This occurs due to damage or dysfunction of the adrenal glands, which leads to inadequate production of these critical hormones.

Cortisol plays essential roles in metabolism, the stress response, and maintaining blood pressure, while aldosterone is vital for regulating electrolyte balance and blood volume. The lack of these hormones results in symptoms such as fatigue, weight loss, low blood pressure, and electrolyte imbalances, among others.

Understanding this hormonal deficiency is crucial in recognizing the clinical manifestations and guiding treatment options for individuals suffering from Addison's disease. While other hormones like thyroid hormones, insulin, and testosterone have significant roles in the body, they are not directly related to the pathology of Addison's disease.