What is required for compatibility when administering fresh frozen plasma (FFP)?

When administering fresh frozen plasma (FFP), the primary requirement for compatibility is ABO compatibility, while there is generally no strict requirement for Rh factor compatibility. This is because plasma contains antibodies that may react with the red blood cells of the recipient; therefore, matching the ABO group is essential to avoid hemolytic reactions.

In terms of Rh factor, while it is ideal to match Rh type when possible, it is not as critical as the ABO compatibility. If an Rh-negative recipient is given Rh-positive plasma, there is minimal risk of immediate adverse reactions since plasma itself does not contain red blood cells. Nonetheless, any Rh antibody response could have implications for future transfusions, which is why some protocols include it as a best practice rather than a strict requirement.

The option stating that complete cross-matching is necessary is not correct for FFP because plasma transfusion primarily concerns the anticoagulant and antibodies rather than the red blood cell antigens, which are the focus of cross-matching. This distinction is essential in understanding the transfusion protocols associated with FFP and its safe administration.