What is the reversal agent for Rocuronium (Zemeron)?

The correct answer is Sugammadex, which is specifically designed to reverse the neuromuscular blockade caused by non-depolarizing neuromuscular blockers like Rocuronium. Sugammadex works by encapsulating the Rocuronium molecules, thus preventing their ability to bind to the nicotinic acetylcholine receptors at the neuromuscular junction. This action facilitates the rapid return of muscle function after surgery or sedation.

While Neostigmine and Pyridostigmine are also agents that can be used for reversal of neuromuscular blockade, they function through a different mechanism. These agents inhibit acetylcholinesterase, leading to an increase in acetylcholine levels at the synapse; however, they are less effective for reversing Rocuronium compared to Sugammadex because they do not specifically target the drug itself. Atropine, on the other hand, is primarily an anticholinergic agent and does not have any role in reversing neuromuscular blockade. Thus, Sugammadex is the most appropriate and effective reversal agent specifically for Rocuronium.