Which of the following is a classic sign of Cushing's syndrome?

Cushing's syndrome is characterized by an excess of cortisol in the body, leading to a range of distinct physical signs and symptoms. One of the most classic signs associated with this condition is the presence of a "buffalo hump." This term refers to the accumulation of fat on the back of the neck and shoulders, which is a hallmark indicator of Cushing's syndrome. This feature results from the redistribution of fat, which occurs due to hormonal imbalances caused by excess cortisol levels.

Weight gain is also a common symptom of Cushing's syndrome. Individuals typically experience central obesity, where fat is primarily distributed in the abdominal area, face, and neck, leading to a rounded face often described as "moon facies." However, the buffalo hump is specifically noted as a distinctive sign of the syndrome that clinicians look for during examination.

Hypotension is generally not associated with Cushing's syndrome; rather, hypertension (high blood pressure) is often seen due to the effects of cortisol on fluid retention and vascular tone. The key features of Cushing's syndrome include obesity, skin changes, hypertension, and the buffalo hump, making this area of physical finding significant in the clinical setting. Thus, while weight gain is relevant, the buffalo hump serves as a particularly