Which symptom is NOT associated with Addison's disease?

Addison's disease, also known as primary adrenal insufficiency, is characterized by the underproduction of adrenal hormones, particularly cortisol and aldosterone. The symptoms of Addison’s disease arise primarily from the deficiency of these hormones and include fatigue, weight loss, low blood pressure, and skin changes.

Cold intolerance is not a recognized symptom of Addison's disease. While some patients with adrenal insufficiency can exhibit symptoms that may be somewhat heterogeneous, cold intolerance typically aligns more closely with hypothyroidism rather than adrenal insufficiency. This is due to the distinct roles that adrenal hormones play in maintaining energy metabolism and regulating fluid balance, which do not directly connect to temperature regulation in the same manner as thyroid hormones.

In contrast, altered mental status can result from the electrolyte imbalances and hypoglycemia seen in Addison's disease. Severe lower extremity pain might be associated with adrenal crisis or related to electrolyte imbalances. Severe vomiting and dehydration are also common symptoms due to the body's inability to retain sodium and water, leading to significant fluid loss. Thus, the other symptoms align more closely with the physiological manifestations of Addison's disease than cold intolerance does.